Ketamine: Rewiring the Depressed BrainHow blocking receptors triggers rapid neural repair

From the show

Psychedelic Mind

Traditional antidepressants take weeks, but Ketamine acts within hours by blocking NMDA receptors. This inhibition triggers a unique paradox: a glutamate surge that stimulates BDNF release, effectively regrowing lost synaptic connections. We examine how this dissociative anesthetic transforms from a club drug to a breakthrough for treatment-resistant depression, physically reconstructing neural pathways in the prefrontal cortex.